Tirzepatide dosing schedule (Zepbound and Mounjaro)

Zepbound and Mounjaro both start at 2.5 mg a week for 4 weeks, then 5 mg. After at least 4 weeks on a dose, it may go up in 2.5 mg steps to a maximum of 15 mg. Add the date of your first injection to download or print a week-by-week log with the label dose for each week.

Adult injection label reference; your prescriber determines the dose and timing. How we check our work Sources

Label schedule, week by week

Tirzepatide once-weekly doses in the FDA labels (earliest timing)
Weeks	Zepbound and Mounjaro	Step
1–4	2.5 mg	First 4 weeks
5–8	5 mg	Increase after 4 weeks
9–12	7.5 mg	Optional
13–16	10 mg	Optional
17–20	12.5 mg	Optional
21 onward	15 mg (maximum)	Optional

The weeks are the earliest each increase can happen. Many people stay at a dose for longer, or stop increasing at 5 mg or 10 mg.

Download or print the log

Add the date of your first injection if you like, and every week gets its date.
Choose Download PDF to save the log and graph, or Print for a paper copy. The log is page 1 and the graph is page 2; weekly dates are included if you entered a start date.
Write down the dose you actually took. If your prescriber holds a dose, it will differ from the label column, and that's expected.

Only your prescriber can decide when to increase, hold or lower a dose. Single-dose Zepbound and Mounjaro pens each deliver one fixed dose.

Correction — November 9, 2026. The simplified “amount in the body” estimate was removed. The chart now shows an illustrative label-dose path only; the log records the dose actually taken separately.

Questions

What is the Zepbound dose schedule?

Per the label: 2.5 mg once a week for 4 weeks, then 5 mg. After at least 4 weeks on the current dose, it may be increased in 2.5 mg steps: 7.5, 10, 12.5 and 15 mg, the maximum. For weight reduction the label lists 5 mg, 10 mg or 15 mg as maintenance doses.

Is Mounjaro dosed the same way?

The steps are the same: 2.5 mg for 4 weeks, then increases of 2.5 mg after at least 4 weeks on each dose, up to 15 mg a week for adults. Mounjaro is labeled for type 2 diabetes and Zepbound for weight reduction and obstructive sleep apnea.

Does everyone go up to 15 mg?

No. Increases after 5 mg are optional, and the label lists 5 mg and 10 mg as maintenance doses for weight reduction as well as 15 mg. Your prescriber decides based on results and side effects.

I use compounded tirzepatide from a vial. Does this apply?

The mg doses can follow the same steps if your prescriber says so, but you measure them in units on a syringe. The tirzepatide calculator turns each mg dose into units for your vial.